Syntheses with stable isotopes: Synthesis of deuterium and13C labeled bile acids
1973; Wiley; Volume: 9; Issue: 4 Linguagem: Inglês
10.1002/jlcr.2590090412
ISSN1559-0860
AutoresDavid L. Hachey, Patricia A. Szczepanik, O. Berngruber, Peter Klein,
Tópico(s)Radiopharmaceutical Chemistry and Applications
ResumoAbstract A series of 5β‐cholanic acids labeled with deuterium in the A ring were prepared by exchange labeling of the corresponding ketone by column chromatography on deuterated alumina. Factors affecting yield and labeling efficiency are discussed. 5β‐Cholanic acids labeled with 13 C in the carboxyl position were prepared by treatment of the corresponding 23‐chloro‐24‐norcholane with sodium cyanide‐ 13 C followed by alkaline hydrolysis of the nitrile. The intermediates in the synthesis were characterized by high resolution NMR spectroscopy. Mass spectra are also reported for the 13 C labeled products.
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