Constitutive activation of NF-kB in human thymocytes
1991; Elsevier BV; Volume: 181; Issue: 1 Linguagem: Inglês
10.1016/s0006-291x(05)81384-1
ISSN1090-2104
AutoresMarie Körner, Nadine Tarantino, Patrice Debré,
Tópico(s)Immunotherapy and Immune Responses
ResumoNF-kB is a eukaryotic transcription regulatory factor. In T cells and T cell lines, NF-kB is bound to a cytoplasmic proteic inhibitor, the IkB. Treatment of T cells with mitogens (phorbol esters) or cytokines (TNF alpha) induces NF-kB nuclear translocation and the subsequent expression of NF-kB dependent T cell genes. Here we examined the activation of NF-kB in human T cell thymic progenitors. We report differences in (Ca2+)i requirement for NF-kB activation in thymocytes as compared to mature T cells. Furthermore, our results indicated that thymocytes have a constitutively active form of NF-kB, suggesting that they are activated in vivo.
Referência(s)