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BIBTEX RIS

The biological activity in mammals and insects of the nucleosidic fraction from the spider Parawixia bistriata

2004; Elsevier BV; Volume: 43; Issue: 4 Linguagem: Inglês

10.1016/j.toxicon.2004.01.009

1879-3150

Marcelo Cairrão Araújo Rodrigues, Renato Guizzo, Leonardo Gobbo‐Neto, Richard J. Ward, Norberto Peporine Lopes, Wagner Ferreira dos Santos,

Beetle Biology and Toxicology Studies

Previous work has shown that the crude venom of Parawixia bistriata induces convulsive seizures in rats after intracerebroventricular injection. In this work, the isolation of a bioactive fraction with ultraviolet absorption characteristics of nucleic acid and trace protein or amino acid content is described. NMR analysis demonstrated that the major component of the active fraction is the nucleoside inosine. An analogue of this component (inosine 5′-monophosphate) induced a delayed paralysis effect in termites.