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ING Proteins in Cellular Senescence

2009; Bentham Science Publishers; Volume: 10; Issue: 5 Linguagem: Inglês

10.2174/138945009788185077

1873-5592

Camino Menéndez, María Abad, Daniel Gómez-Cabello, Alberto Moreno, Ignacio Palmero,

S100 Proteins and Annexins

Cellular senescence is an effective anti-tumor barrier that acts by restraining the uncontrolled proliferation of cells carrying potentially oncogenic alterations. ING proteins are putative tumor suppressor proteins functionally linked to the p53 pathway and to chromatin regulation. ING proteins exert their tumor-protective action through different types of responses. Here, we review the evidence on the participation of ING proteins, mainly ING1 and ING2, in the implementation of the senescent response. The currently available data support an important role of ING proteins as regulators of senescence, in connection with the p53 pathway and chromatin organization.