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BIBTEX RIS

Regulation of transient receptor potential (TRP) channels by phosphoinositides

2007; Springer Science+Business Media; Volume: 455; Issue: 1 Linguagem: Inglês

10.1007/s00424-007-0275-6

ISSN

1432-2013

Autores

Tibor Rohács, Bernd Nilius,

Tópico(s)

Neurobiology and Insect Physiology Research

Resumo

This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP2) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP2 and discusses some future challenges of this fascinating topic.

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