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Antiinflammatory effect of Japanese‐Sino medicine ‘Keishi‐ka‐jutsubu‐to’ and its component drugs on adjuvant air pouch granuloma of mice

1991; Wiley; Volume: 5; Issue: 5 Linguagem: Inglês

10.1002/ptr.2650050502

1099-1573

Masayasu Kimura, Ikuko Kimura, Bao Luo, Shinjiro Kobayashi,

Plant-based Medicinal Research

Abstract A Japanese‐Sino medicine, Keishi‐ka‐jutsubu‐to (KJ), consisting of seven crude drugs, aconite, Atractylodes lancea , peony, liquorice, ginger, cassia and jujube, has long been used clinically to cure chronic inflammatory diseases such as rheumatoid arthritis. The antiinflammatory effect induced by KJ and the main roles of the component crude drugs in KJ were investigated on adjuvant‐induced air pouch granuloma in mice. KJ (water‐soluble extract at 50°C) was effective in inhibiting the chronic inflammatory process of angiogenesis, whereas KJ (extract at 100°C without a water‐cooler) was effective for the acute inflammatory processes of inflammatory cell migration and pouch fluid exudation. Keishi‐to (KJ minus aconite and Atractylodes lancea ) and a combination of both aconite and Atractylodes lancea provided additive inhibition of angiogenesis when used in combination. The interaction between aconite and Atractylodes lancea also produced additive inhibition. The effects on angiogenesis of peony, ginger or cassia alone were potentiated, and those of aconite, Atractylodes lancea or liquorice alone were additive in KJ. Pharmacological analysis of these experimental chronic inflammatory processes demonstrated the role of each drug in the combined effect of KJ.