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BIBTEX RIS

Transmission Fitness of Drug‐Resistant Human Immunodeficiency Virus and the Prevalence of Resistance in the Antiretroviral‐Treated Population

2003; Oxford University Press; Volume: 187; Issue: 4 Linguagem: Inglês

10.1086/367989

ISSN

1537-6613

Autores

Andrew Brown, Simon D. W. Frost, W. Christopher Mathews, Keith M. Dawson, Nicholas S. Hellmann, Eric S. Daar, Douglas D. Richman, Susan J. Little,

Tópico(s)

HIV/AIDS Research and Interventions

Resumo

Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only ∼20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains

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