Capillary Leak Syndrome Likely the Result of Granulocyte Colony-Stimulating Factor after High-Dose Chemotherapy.
1994; The Japanese Society of Internal Medicine; Volume: 33; Issue: 2 Linguagem: Inglês
10.2169/internalmedicine.33.115
ISSN1349-7235
AutoresEiichi Oeda, Kenji Shinohara, Shinji Kamei, Jun Nomiyama, Hirofumi Inoue,
Tópico(s)Methemoglobinemia and Tumor Lysis Syndrome
ResumoTwo cases of malignant lymphoma complicated with capillary leak syndrome following super high-dose chemotherapy and administration of granulocyte colony-stimulating factor (G-CSF) are presented. Subsequent to the nadir of granulocytes, and at the stage of rapid increase of granulocytes, the symptoms of fever, hypotension, dyspnea, pleural effusion and edema appeared, and laboratory data revealed hypoxia, hypocapnia and hypoalbuminemia. In addition, an abscesslike lesion was observed in the liver in one patient. After the administration of G-CSF was ceased or decreased, and pulse therapy with methylprednisolone was initiated, these symptoms disappeared quickly.(Internal Medicine 33:115-119, 1994)
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