Artigo Revisado por pares

Three years in reviews

2009; American Physiological Society; Volume: 298; Issue: 3 Linguagem: Inglês

10.1152/ajpendo.00770.2009

ISSN

1522-1555

Autores

Amira Klip,

Tópico(s)

Growth Hormone and Insulin-like Growth Factors

Resumo

EDITORIALThree years in reviewsAmira Klip, Amira Klip, Editor-in-ChiefPublished Online:01 Mar 2010https://doi.org/10.1152/ajpendo.00770.2009This is the final version - click for previous versionMoreSectionsPDF (79 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat as we ring in 2010, I am delighted to highlight a few of our accomplishments, and I take the opportunity to congratulate our authors, reviewers, and Associate Editors for their continued excellence and collegiality. It is undeniable that AJP - Endocrinology and Metabolism has played a pivotal role in the fields of energy metabolism and reproductive physiology as well as having a growing presence in the field of bone metabolism. In energy metabolism, the Journal has been a mainstay of the scientific literature for over three decades, presenting many of the most fundamental discoveries in endocrine regulation of glucose, fat and protein metabolism, exercise physiology, and diabetes. In the past three years, the Journal has added a dimension to this contribution by being the home to seminal discoveries in the area of central nervous control of energy metabolism and the control of appetite. This burgeoning field of research has, in turn, enhanced the Journal's visibility and identification as a portal for forefront research.I congratulate the many authors worldwide whose work we have published over the past three years. In analyzing the breadth and scope of such research, we are also impressed by the international face of our Journal. The studies published have been performed in many countries and from essentially all continents of the planet. Along with the other APS journals, we take pride in providing open and transparent review of scientific reports by all authors irrespective of gender, nationality, or affiliation. It is the quality of the study, and not the reputation of the authors, that drive the peer review process.As we climb the bell tower to ring in the New Year, I want to bang the drums to celebrate the numerous Review articles that we have published throughout the last three years. These contributions, listed below, represent a tremendous wealth of knowledge that we disseminate around the academic world. They are useful in guiding science, inspiring the next questions, and helping students and professors alike in their presentations and reports. Many of these invited review articles have been published in clusters, and although the entire complement may not always be published in the same issue, the components are linked through Editorial Focus articles that are in themselves creative and of added value (see Table 1). Additional Editorial Focus articles are sometimes commissioned to highlight particularly innovative, accepted research articles (see Table 4). In some cases, invited reviews (see Table 2) are more a view to the future than to the past, and in those cases we've labeled them Perspectives, and when the forefront wave of a field was highlighted, we've labeled them Frontiers. The latter was sometimes the vehicle used to introduce the work of our Associate Editors to our readership. We've also highlighted and profiled APS award winners by inviting submission of their award lecture presentations (see Table 3) as review articles for the enjoyment of the entire community—such reviews are exemplified by the Berson Award Lecture, presented at the annual Experimental Biology meeting. Moreover, we are proud to highlight from time to time a life-long account of research by a prominent investigator. Finally, we are delighted to be a gateway for Essays on APS Classic Papers. These are invited analytical papers (see Table 5) that explore the impact of designated classical papers in our AJP - Endocrinology and Metabolism archives. We thank the authors of all invited articles for their insights and timeliness in delivering their work, which in all cases undergoes the same high-quality peer review as do all of our original research manuscripts.Table 1. ClustersClustersClusterMETABOLIC SENSING AND THE HYPOTHALAMUSEditorial Focus:Martin G. Myers, Jr.Metabolic sensing and regulation by the hypothalamusAm J Physiol Endocrinol Metab 294: E809–E809, 2008; doi:10.1152/ajpendo.90282.2008ReviewsEva Rother, A. Christine Könner, And Jens C. BrüningNeurocircuits integrating hormone and nutrient signaling in control of glucose metabolismAm J Physiol Endocrinol Metab 294: E810–E816, 2008. First published February 19, 2008; doi:10.1152/ajpendo.00685.2007Qian Gao And Tamas L. HorvathCross-talk between estrogen and leptin signaling in the hypothalamusAm J Physiol Endocrinol Metab 294: E817–E826, 2008. First published March 11, 2008; doi:10.1152/ajpendo.00733.2007Jennifer W. Hill, Joel K. Elmquist, And Carol F. EliasHypothalamic pathways linking energy balance and reproductionAm J Physiol Endocrinol Metab 294: E827–E832, 2008. First published February 19, 2008; doi:10.1152/ajpendo.00670.2007See Related Review By Y-H Jo And S. Chua In Accompanying List Of Individual ReviewsClusterMETABOLIC EFFECTS OF ALCOHOLEditorial Focus:Patricia E. MolinaAlcohol—intoxicating roadblocks and bottlenecks in hepatic protein and lipid metabolismAm J Physiol Endocrinol Metab 295: E1–E2, 2008. First published May 13, 2008; doi:10.1152/ajpendo.90412.2008ReviewsAnne M. Karinch, Jonathan H. Martin, And Thomas C. VaryAcute and chronic ethanol consumption differentially impact pathways limiting hepatic protein synthesisAm J Physiol Endocrinol Metab 295: E3-E9, 2008. First published March 11, 2008; doi:10.1152/ajpendo.00026.2008Margaret Sozio And David W. CrabbAlcohol and lipid metabolismAm J Physiol Endocrinol Metab 295: E10–E16, 2008. First published March 18, 2008; doi:10.1152/ajpendo.00011.2008ClusterFACILITATIVE GLUCOSE TRANSPORTERSOverall ReviewBernard Thorens and Michael MuecklerGlucose transporters in the 21st Century Am J Physiol Endocrinol Metab (December 15, 2009).doi:10.1152/ajpendo.00712.2009Editorial FocusAnnette SchürmannInsight into the “odd” hexose transporters GLUT3, GLUT5, and GLUT7Am J Physiol Endocrinol Metab 295: E225–E226, 2008. First published May 6, 2008; doi:10.1152/ajpendo.90406.2008ReviewsAnthony Carruthers, Julie Dezutter, Amit Ganguly, And Sherin U. DevaskarWill the original glucose transporter isoform please stand up!Am J Physiol Endocrinol Metab 297: E836–E848, 2009. First published August 18, 2009; doi:10.1152/ajpendo.00496.2009Armelle Leturque, Edith Brot-Laroche, And Maude Le GallGLUT2 mutations, translocation, and receptor function in diet sugar managingAm J Physiol Endocrinol Metab 296: E985–E992, 2009. First published February 17, 2009; doi:10.1152/ajpendo.00004.2009Ian A. Simpson, Donard Dwyer, Daniela Malide, Kelle H. Moley, Alexander Travis, And Susan J. VannucciThe facilitative glucose transporter GLUT3: 20 yr of distinctionAm J Physiol Endocrinol Metab 295: E242–E253, 2008. First published June 24, 2008; doi:10.1152/ajpendo.90388.2008Eddy Karnieli And Michal ArmoniTranscriptional regulation of the insulin-responsive glucose transporter GLUT4 gene: from physiology to pathologyAm J Physiol Endocrinol Metab 295: E38–E45, 2008. First published May 20, 2008; doi:10.1152/ajpendo.90306.2008Veronique Douard And Ronaldo P. FerrarisRegulation of the fructose transporter GLUT5 in health and diseaseAm J Physiol Endocrinol Metab 295: E227–E237, 2008. First published April 8, 2008; doi:10.1152/ajpendo.90245.2008Chris CheesemanGLUT7: a new intestinal facilitated hexose transporterAm J Physiol Endocrinol Metab 295: E238–E241, 2008. First published May 13, 2008; doi:10.1152/ajpendo.90394.2008Stefan Schmidt, Hans-Georg Joost, And Annette SchürmannGLUT8, the enigmatic intracellular hexose transporterAm J Physiol Endocrinol Metab 296: E614–E618, 2009. First published January 27, 2009; doi:10.1152/ajpendo.91019.2008Manuel Doblado And Kelle H. MoleyFacilitative glucose transporter 9, a unique hexose and urate transporterAm J Physiol Endocrinol Metab 297: E831–E835, 2009. First published June 30, 2009; doi:10.1152/ajpendo.00296.2009See Related Reviews By Sakamoto And Holman, And By Shisheva In Accompanying List Of Individual ReviewsClusterTRIGGERS FOR INSULIN SECRETIONEditorial FocusPhilippe A. HalbanThe right stuff: β-cell channels, cycles, and sensorsAm J Physiol Endocrinol Metab 295: E1277–E1278, 2008. First published August 19, 2008; doi:10.1152/ajpendo.90692.2008ReviewsBenoit R. Gauthier And Claes B. WollheimSynaptotagmins bind calcium to release insulinAm J Physiol Endocrinol Metab 295: E1279–E1286, 2008. First published August 19, 2008; doi:10.1152/ajpendo.90568.2008Mette V. Jensen, Jamie W. Joseph, Sarah M. Ronnebaum, Shawn C. Burgess, A. Dean Sherry, And Christopher B. NewgardMetabolic cycling in control of glucose-stimulated insulin secretionAm J Physiol Endocrinol Metab 295: E1287–E1297, 2008. First published August 26, 2008; doi:10.1152/ajpendo.90604.2008Marcia Hiriart And Lydia Aguilar-BryanChannel regulation of glucose sensing in the pancreatic β-cellAm J Physiol Endocrinol Metab 295: E1298–E1306, 2008. First published October 21, 2008; doi:10.1152/ajpendo.90493.2008See Related Review By Bertram Et Al. In Accompanying List Of Individual ReviewsClusterPOSTTRANSLATIONAL MODIFICATIONS AS NOVEL METABOLIC SIGNALSEditorial FocusAndré MaretteNew insights in covalent modifications of proteins and lipids: phosphorylation and beyondAm J Physiol Endocrinol Metab 296: E579–E580, 2009. First published January 27, 2009; doi:10.1152/ajpendo.00049.2009ReviewsSigalit Boura-Halfon And Yehiel ZickPhosphorylation of IRS proteins, insulin action, and insulin resistanceAm J Physiol Endocrinol Metab 296: E581–E591, 2009. First published August 26, 2008; doi:10.1152/ajpendo.90437.2008Ronald J. Copeland, John W. Bullen, And Gerald W. HartCross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicityAm J Physiol Endocrinol Metab 295: E17–E28, 2008. First published April 29, 2008; doi:10.1152/ajpendo.90281.2008ClusterAMINO ACID SIGNALINGJoseph Avruch, Xiaomeng Long, Sara Ortiz-Vega, Joseph Rapley, Angela Papageorgiou, And Ning DaiAmino acid regulation of TOR complex 1Am J Physiol Endocrinol Metab 296: E592–E602, 2009. First published September 2, 2008; doi:10.1152/ajpendo.90645.2008Harinder S. Hundal And Peter M. TaylorAmino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signalingAm J Physiol Endocrinol Metab 296: E603–E613, 2009. First published January 21, 2009; doi:10.1152/ajpendo.91002.2008Cluster:NEUTRAL LIPIDS METABOLISM AND IMPLICATIONSEditorial FocusDong ChengFat for life: new stories on old greaseAm J Physiol Endocrinol Metab 296: E1181–E1182, 2009. First published December 23, 2008; doi:10.1152/ajpendo.90993.2008ReviewsJahangir Iqbal and M. Mahmood HussainIntestinal lipid absorptionAm J Physiol Endocrinol Metab 296: E1183–E1194, 2009. First published January 21, 2009; doi:10.1152/ajpendo.90899.2008Kazuharu Takeuchi and Karen ReueBiochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesisAm J Physiol Endocrinol Metab 296: E1195–E1209, 2009. First published March 31, 2009; doi:10.1152/ajpendo.90958.2008Ta-Yuan Chang, Bo-Liang Li, Catherine C. Y. Chang, and Yasuomi UranoAcyl-coenzyme A:cholesterol acyltransferasesAm J Physiol Endocrinol Metab 297: E1–E9, 2009. First published January 13, 2009; doi:10.1152/ajpendo.90926.2008Yuguang Shi and Dong ChengBeyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolismAm J Physiol Endocrinol Metab 297: E10–E18, 2009. First published December 30, 2008; doi:10.1152/ajpendo.90949.2008Aaron R. Turkish and Stephen L. SturleyThe genetics of neutral lipid biosynthesis: an evolutionary perspectiveAm J Physiol Endocrinol Metab 297: E19–E27, 2009. First published December 30, 2008; doi:10.1152/ajpendo.90898.2008Chad M. Paton and James M. NtambiBiochemical and physiological function of stearoyl-CoA desaturaseAm J Physiol Endocrinol Metab 297: E28–E37, 2009. First published December 9, 2008; doi:10.1152/ajpendo.90897.2008Hong Wang and Robert H. EckelLipoprotein lipase: from gene to obesityAm J Physiol Endocrinol Metab 297: E271–E288, 2009. First published March 24, 2009; doi:10.1152/ajpendo.90920.2008Martina Schweiger, Achim Lass, Robert Zimmermann, Thomas O. Eichmann, and Rudolf ZechnerNeutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5Am J Physiol Endocrinol Metab 297: E289–E296, 2009. First published April 28, 2009; doi:10.1152/ajpendo.00099.2009Richard W. Gross and Xianlin HanShotgun lipidomics of neutral lipids as an enabling technology for elucidation of lipid-related diseasesAm J Physiol Endocrinol Metab 297: E297–E303, 2009. First published January 6, 2009; doi:10.1152/ajpendo.90970.2008See related review by Moro et al. in accompanying list of individual reviewsClusterORGAN CROSS-TALK AND METABOLIC RISKEditorial FocusFrancesco GiorginoAdipose tissue function and dysfunction: organ cross talk and metabolic riskAm J Physiol Endocrinol Metab 297: E975–E976, 2009. First published August 25, 2009; doi:10.1152/ajpendo.00488.2009ReviewsSaverio CintiTransdifferentiation properties of adipocytes in the adipose organAm J Physiol Endocrinol Metab 297: E977–E986, 2009. First published May 19, 2009; doi:10.1152/ajpendo.00183.2009Roberto Vettor, Gabriella Milan, Chiara Franzin, Marta Sanna, Paolo De Coppi, Rosario Rizzuto, and Giovanni FederspilThe origin of intermuscular adipose tissue and its pathophysiological implicationsAm J Physiol Endocrinol Metab 297: E987–E998, 2009. First published September 8, 2009; doi:10.1152/ajpendo.00229.2009Birgit Gustafson, Silvia Gogg, Shahram Hedjazifar, Lachmi Jenndahl, Ann Hammarstedt, and Ulf SmithInflammation and impaired adipogenesis in hypertrophic obesity in manAm J Physiol Endocrinol Metab 297: E999–E1003, 2009. First published July 21, 2009; doi:10.1152/ajpendo.00377.2009Annika Taube, Kristin Eckardt, and Juergen EckelRole of lipid-derived mediators in skeletal muscle insulin resistanceAm J Physiol Endocrinol Metab 297: E1004–E1012, 2009. First published July 14, 2009; doi:10.1152/ajpendo.00241.2009See related review by Lee et al. in accompanying list of individual reviewsTable 2. Individual reviewsIndividual ReviewsFrontiersCharles H. Lang, Robert A. Frost, And Thomas C. VaryRegulation of muscle protein synthesis during sepsis and inflammationAm J Physiol Endocrinol Metab 293: E453–E459, 2007. First published May 15, 2007; doi:10.1152/ajpendo.00204.2007See Related Review By Smith Et Al. In This ListPhilip E. Dubé And Patricia L. BrubakerFrontiers in glucagon-like peptide-2: multiple actions, multiple mediatorsAm J Physiol Endocrinol Metab 293: E460–E465, 2007. First published July 24, 2007; doi:10.1152/ajpendo.00149.2007Bernhard Aigner, Birgit Rathkolb, Nadja Herbach, Martin Hrabé De Angelis, Rüdiger Wanke, And Eckhard WolfDiabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projectsAm J Physiol Endocrinol Metab 294: E232–E240, 2008. First published December 4, 2007; doi:10.1152/ajpendo.00592PerspectivesBoubacar Benziane And Alexander V. ChibalinFrontiers: Skeletal muscle sodium pump regulation: a translocation paradigmAm J Physiol Endocrinol Metab 295: E553–E558, 2008. First published April 22, 2008; doi:10.1152/ajpendo.90261.2008Julia Kovsan, Nava Bashan, Andrew S. Greenberg, And Assaf RudichPotential role of autophagy in modulation of lipid metabolismAm J Physiol Endocrinol Metab (November 3, 2009).doi:10.1152/ajpendo.00562.2009Account Of Lifetime ResearchMichael G. ClarkImpaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscleAm J Physiol Endocrinol Metab 295: E732–E750, 2008. First published July 8, 2008; doi:10.1152/ajpendo.90477.2008For 2010: Expecting An Account On Lifetime Research By Mladen VranicReviewsRichard Bertram, Arthur Sherman, and Leslie S. SatinMetabolic and electrical oscillations: partners in controlling pulsatile insulin secretionAm J Physiol Endocrinol Metab 293: E890–E900, 2007. First published July 31, 2007; doi:10.1152/ajpendo.00359.2007See related reviews on triggers for insulin secretion in accompanying list of clustersClaude Roberge, André C. Carpentier, Marie-France Langlois, Jean-Patrice Baillargeon, Jean-Luc Ardilouze, Pierre Maheux, and Nicole Gallo-PayetAdrenocortical dysregulation as a major player in insulin resistance and onset of obesityAm J Physiol Endocrinol Metab 293: E1465–E1478, 2007. First published October 2, 2007; doi:10.1152/ajpendo.00516.2007Cheryl A. ConoverInsulin-like growth factor-binding proteins and bone metabolismAm J Physiol Endocrinol Metab 294: E10–E14, 2008. First published November 14, 2007; doi:10.1152/ajpendo.00648.2007Ranganath Muniyappa, Sihoon Lee, Hui Chen, and Michael J. QuonCurrent approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usageAm J Physiol Endocrinol Metab 294: E15–E26, 2008. First published October 23, 2007; doi:10.1152/ajpendo.00645.2007Owen P. McGuinness, Julio E. Ayala, Maren R. Laughlin, and David H. WassermanNIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouseAm J Physiol Endocrinol Metab 297: E849–E855, 2009. First published July 28, 2009; doi:10.1152/ajpendo.90996.2008Melanie G. Cree and Robert R. WolfePostburn trauma insulin resistance and fat metabolismAm J Physiol Endocrinol Metab 294: E1–E9, 2008. First published October 23, 2007; doi:10.1152/ajpendo.00562.2007Cédric Moro, Sudip Bajpeyi, and Steven R. SmithDeterminants of intramyocellular triglyceride turnover: implications for insulin sensitivityAm J Physiol Endocrinol Metab 294: E203–E213, 2008. First published November 14, 2007; doi:10.1152/ajpendo.00624.2007See related Reviews on Neutral Lipids Metabolism and Implications in accompanying list of Clusters.Anthony E. PeggSpermidine/spermine-N1-acetyltransferase: a key metabolic regulatorAmJ Physiol Endocrinol Metab 294: E995–E1010, 2008. First published March 18, 2008; doi:10.1152/ajpendo.90217.2008Kei Sakamoto and Geoffrey D. HolmanEmerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 trafficAm J Physiol Endocrinol Metab 295: E29–E37, 2008. First published May 13, 2008; doi:10.1152/ajpendo.90331.2008Sylvia Santosa and Michael D. JensenWhy are we shaped differently, and why does it matter?Am J Physiol Endocrinol Metab 295: E531–E535, 2008. First published May 20, 2008; doi:10.1152/ajpendo.90357.2008Assia ShishevaPhosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3Am J Physiol Endocrinol Metab 295: E536–E544, 2008. First published May 20, 2008; doi:10.1152/ajpendo.90353.2008Yun Chau Long and Juleen R. ZierathInfluence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscleAm J Physiol Endocrinol Metab 295: E545–E552, 2008. First published June 10, 2008; doi:10.1152/ajpendo.90259.2008Pritpal Bansal and Qinghua WangInsulin as a physiological modulator of glucagon secretionAm J Physiol Endocrinol Metab 295: E751–E761, 2008. First published July 22, 2008; doi:10.1152/ajpendo.90295.2008Ira J. Smith, Stewart H. Lecker, and Per-Olof HasselgrenCalpain activity and muscle wasting in sepsisAm J Physiol Endocrinol Metab 295: E762–E771, 2008. First published May 20, 2008; doi:10.1152/ajpendo.90226.2008See related Frontiers by Lang et al. in this listCarmen Clapp, Stéphanie Thebault, Edith Arnold, Celina García, José Carlos Rivera, and Gonzalo Martínez de la EscaleraVasoinhibins: novel inhibitors of ocular angiogenesisAm J Physiol Endocrinol Metab 295: E772–E778, 2008. First published June 10, 2008; doi:10.1152/ajpendo.90358.2008Luigi Laviola, Annalisa Natalicchio, Sebastio Perrini, and Francesco GiorginoAbnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humansAm J Physiol Endocrinol Metab 295: E991–E999, 2008. First published August 19, 2008; doi:10.1152/ajpendo.90452.2008Alessandro Laviano, Akio Inui, Daniel L. Marks, Michael M. Meguid, Claude Pichard, Filippo Rossi Fanelli, and Marilia SeelaenderNeural control of the anorexia-cachexia syndromeAm J Physiol Endocrinol Metab 295: E1000–E1008, 2008. First published August 19, 2008; doi:10.1152/ajpendo.90252.2008Jose E. Galgani, Cedric Moro, and Eric RavussinMetabolic flexibility and insulin resistanceAm J Physiol Endocrinol Metab 295: E1009–E1017, 2008. First published September 2, 2008; doi:10.1152/ajpendo.90558.2008Taila Hartley, John Brumell, and Allen VolchukEmerging roles for the ubiquitin-proteasome system and autophagy in pancreatic β-cellsAm J Physiol Endocrinol Metab 296: E1–E10, 2009. First published September 23, 2008; doi:10.1152/ajpendo.90538.2008Sathyaseelan S. Deepa and Lily Q. DongAPPL1: role in adiponectin signaling and beyondAm J Physiol Endocrinol Metab 296: E22–E36, 2009. First published October 14, 2008; doi:10.1152/ajpendo.90731.2008Xu Tan and Ning ZhengHormone signaling through protein destruction: a lesson from plantsAm J Physiol Endocrinol Metab 296: E223–E227, 2009. First published December 2, 2008; doi:10.1152/ajpendo.90807.2008John A. Williams, Xuequn Chen, and Maria E. SabbatiniSmall G proteins as key regulators of pancreatic digestive enzyme secretionAm J Physiol Endocrinol Metab 296: E405–E414, 2009. First published December 16, 2008; doi:10.1152/ajpendo.90874.2008Safina Ali and Daniel J. DruckerBenefits and limitations of reducing glucagon action for the treatment of type 2 diabetesAm J Physiol Endocrinol Metab 296: E415–E421, 2009. First published December 30, 2008; doi:10.1152/ajpendo.90887.2008Jasmine V. Abella and Morag ParkBreakdown of endocytosis in the oncogenic activation of receptor tyrosine kinasesAm J Physiol Endocrinol Metab 296: E973–E984, 2009. First published February 24, 2009; doi:10.1152/ajpendo.90857.2008Do-Eun Lee, Sylvia Kehlenbrink, Hanna Lee, Meredith Hawkins, and John S. YudkinGetting the message across: mechanisms of physiological cross talk by adipose tissueAm J Physiol Endocrinol Metab 296: E1210–E1229, 2009. First published March 3, 2009; doi:10.1152/ajpendo.00015.2009Mi-Jeong Lee and Susan K. FriedIntegration of hormonal and nutrient signals that regulate leptin synthesis and secretionAm J Physiol Endocrinol Metab 296: E1230–E1238, 2009. First published March 24, 2009; doi:10.1152/ajpendo.90927.2008Young-Hwan Jo and Streamson Chua, Jr.Transcription factors in the development of medial hypothalamic structuresAm J Physiol Endocrinol Metab 297: E563–E567, 2009. First published April 21, 2009; doi:10.1152/ajpendo.00064.2009See related reviews on metabolc sensing and the hypothalamus in accompanying list of clustersMaria Assunta Potenza, Francesco Addabbo, and Monica MontagnaniVascular actions of insulin with implications for endothelial dysfunctionAm J Physiol Endocrinol Metab 297: E568–E577, 2009. First published June 2, 2009; doi:10.1152/ajpendo.00297.2009Louis Hue and Heinrich TaegtmeyerThe Randle cycle revisited: a new head for an old hatAm J Physiol Endocrinol Metab 297: E578–E591, 2009. First published June 16, 2009; doi:10.1152/ajpendo.00093.2009David L. Morris and Liangyou RuiRecent advances in understanding leptin signaling and leptin resistanceAm J Physiol Endocrinol Metab 297: E1247–E1259, 2009. First published September 1, 2009; doi:10.1152/ajpendo.00274.2009Anna Gumà, Vicente Martínez-Redondo, Iliana López-Soldado, Carles Cantó, Antonio ZorzanoEmerging role of neuregulin as a modulator of muscle metabolismAm J Physiol Endocrinol Metab, First published December 22, 2009; doi:10.1152/ajpendo.00541.2009Table 3. Award lecture reviewsAward Lecture Foci And ReviewsThe Aps Walter B. Cannon Lecture, 2007Editorial FocusDale BenosFrances Ashcroft: 2007 Walter B. Cannon Physiology in Perspective LectureAm J Physiol Endocrinol Metab 293: E879–E879, 2007. First published August 21, 2007; doi:10.1152/ajpendo.00530.2007The Walter B. Cannon Physiology In Perspective Lecture, 2007Frances M. AshcroftATP-sensitive K+ channels and disease: from molecule to maladyAm J Physiol Endocrinol Metab 293: E880–E889, 2007. First published July 24, 2007; doi:10.1152/ajpendo.00348.2007The Aps Young Scientist AwardEditorial FocusAmira KlipKei on GSK: a contribution by the 2007 recipient of the Young Scientist AwardAm J Physiol Endocrinol Metab 294: E27–E27, 2008. First published November 27, 2007; doi:10.1152/ajpendo.00731.2007Original ResearchMichale Bouskila, Michael F. Hirshman, Jørgen Jensen, Laurie J. Goodyear, And Kei SakamotoInsulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscleAm J Physiol Endocrinol Metab 294: E28–E35, 2008. First published November 14, 2007; doi:10.1152/ajpendo.00481.2007The Aps Berson Award 2008ReviewDavid H. WassermanFour grams of glucose. Berson Award LectureAm J Physiol Endocrinol Metab 296: E11–E21, 2009. First published October 7, 2008; doi:10.1152/ajpendo.90563.2008The Aps Berson Award 2009Editorial FocusWillis K. SamsonThe search for the membrane thyroid hormone receptorAm J Physiol Endocrinol Metab 297: E1237–E1237, 2009. First published August 25, 2009; doi:10.1152/ajpendo.00502.2009ReviewPaul J. Davis, Faith B. Davis, Hung-Yun Lin, Shaker A. Mousa, Min Zhou, and Mary K. LuidensTranslational implications of nongenomic actions of thyroid hormone initiated at its integrin receptorAm J Physiol Endocrinol Metab 297: E1238–E1246, 2009. First published September 15, 2009; doi:10.1152/ajpendo.00480.2009Table 4. Editorial foci on original research articlesEditorial Foci on Original ArticlesEditorial FocusMatthias H. Tschöp And Eric RavussinPeptide YY: obesity's cause and cure?Am J Physiol Endocrinol Metab 293: E1131-E1133, 2007. First published September 11, 2007; doi:10.1152/ajpendo.00568.2007Original ResearchAstrup A, Casanova M, Davidsen L, Flint A, Holst Jj, Sloth B.Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males. Am J Physiol Endocrinol Metab 293: E604–E609, 2007Astrup A, Flint A, Gregersen Nt, Holst Jj, Sloth B.Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, and glucose and fat metabolism in obese and lean subjects. Am J Physiol Endocrinol Metab 292: E1062–E1068, 2007Editorial FocusVincent PoitoutPhospholipid hydrolysis and insulin secretion: a step toward solving the Rubik's cubeAm J Physiol Endocrinol Metab 294: E214–E216, 2008. First published October 9, 2007; doi:10.1152/ajpendo.00638.2007Original ResearchShunzhong Bao, David A. Jacobson, Mary Wohltmann, Alan Bohrer, Wu Jin, Louis H. Philipson, And John TurkGlucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2β in pancreatic β-cells and in iPLA2β-null miceAm J Physiol Endocrinol Metab 294: E217–E229, 2008. First published September 25, 2007; doi:10.1152/ajpendo.00474.2007Editorial FocusStuart M. PhillipsInsulin and muscle protein turnover in humans: stimulatory, permissive, inhibitory, or all of the above?Am J Physiol Endocrinol Metab 295: E731–E731, 2008. First published July 15, 2008; doi:10.1152/ajpendo.90569.2008Original ResearchP. L. Greenhaff, L. G. Karagounis, N. Peirce, E. J. Simpson, M. Hazell, R. Layfield, H. Wackerhage, K. Smith, P. Atherton, A. Selby, And M. J. RennieDisassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscleAm J Physiol Endocrinol Metab, Sep 2008; 295: E595–E604.Editorial FocusSarah Haas Lockie, Timo D. Müller, And Matthias H. TschöpCoupled with uncouplers: the curious case of lifespanAm J Physiol Endocrinol Metab 296: E619–E620, 2009. First published February 10, 2009; doi:10.1152/ajpendo.00060.2009Original ResearchZane B. Andrews And Tamas L. HorvathUncoupling protein-2 regulates lifespan in miceAm J Physiol Endocrinol Metab 296: E621–E627, 2009. First published January 13, 2009; doi:10.1152/ajpendo.90903.2008Editorial FocusPhilip J. Bilan And Jonathan D. SchertzerBrought in by force: AMPK, TBC1D1, and contraction-stimulated glucose transport in skeletal muscleAm J Physiol Endocrinol Metab 296: E965–E966, 2009. First published March 3, 2009; doi:10.1152/ajpendo.00101.2009Original ResearchDavid R. Blair, Katsuhiko Funai, George G. Schweitzer, And Gregory D. CarteeA myosin II ATPase inhibitor reduces force production, glucose transport, and phosphorylation of AMPK and TBC1D1 in electrically stimulated rat skeletal muscleAm J Physiol Endocrinol Metab 296: E993–E1002, 2009. First published Feb 3, 2009; doi:10.1152/ajpendo.91003.2008Editorial FocusBrendan Egan And Juleen R. ZierathHunting for the SNARK in metabolic diseaseAm J Physiol Endocrinol Metab 296: E969–E972, 2009. First published March 24, 2009; doi:10.1152/ajpendo.00178.2009Original ResearchNoriko Ichinoseki-Sekine, Hisashi Naito, Katsuya Tsuchihara, Ikumi Kobayashi, Yuji Ogura, Ryo Kakigi, Mitsutoshi Kurosaka, Rumi Fujioka, And Hiroyasu EsumiProvision of a voluntary exercise environment enhances running activity and prevents obesity in Snark-deficient miceAm J Physiol Endocrinol Metab 296: E1013–E1021, 2009. First published Mar 10, 2009; doi:10.1152/ajpendo.90891.2008Editorial FocusGary J. SchwartzYour brain on fat: dietary-induced obesity impairs central nutrient sensingAm J Physiol Endocrinol Metab 296: E967–E968, 2009. First published March 24, 2009; doi:10.1152/ajpendo.00177.2009Original ResearchKelly A. Posey, Deborah J. Clegg, Richard L. Printz, Jaeman Byun, Gregory J. Morton, Anuradha Vivekanandan-Giri, Subramaniam Pennathur, Denis G. Baskin, Jay W. Heinecke, Stephen C. Woods, Michael W. Schwartz, And Kevin D. NiswenderHypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat dietAm J Physiol Endocrinol Metab. 296:E1003–E1012, 2008. First published December 30, 2008.doi:10.1152/ajpendo.90377.2008Table 5. Essays on classic papersEssays On Classic PapersDavid B. BylundAlpha- and beta-adrenergic receptors: Ahlquist's landmark hypothesis of a single mediator with two receptorsAm J Physiol Endocrinol Metab 293: E1479–E1481, 2007. First published October 23, 2007; doi:10.1152/ajpendo.00664.2007In reference to:Raymond P. AhlquistA study of adrenotropic receptorsAm J Physiol 153: 586–600, 1948 (http://ajplegacy.physiology.org/cgi/reprint/153/3/586)Marcas M. BammanThe exercise dose response: key lessons from the pastAm J Physiol Endocrinol Metab 294: E230–E231, 2008. First published December 26, 2007; doi:10.1152/ajpendo.00787.2007In reference to:Fitts RH, Booth FW, Winder WW, Holloszy JO.Skeletal muscle respiratory capacity, endurance, and glycogen utilizationAm J Physiol 228: 1029-133, 1975. PMID: 18160457 (http://ajplegacy.physiology.org/cgi/reprint/228/4/1029)I also thank the entire team of Associate Editors that has participated in the peer review of these articles, on top of their extraordinary work toward the original research articles submitted. Each of the eight Associate Editors of our Journal (Pat Brubaker, Meredith Hawkins, Chuck Lang, André Marette, Kelle Moley, Martin Myers, Michael Quon, and Juleen Zierath) handled, on average, 135 to 150 papers per year, assigning reviewers, making decisions, and communicating them to the authors. As our third year together has ended, Meredith Hawkins has concluded her work with the team, and I am delighted to have welcomed Assaf Rudich as a new Associate Editor (in office since October 2009). Just as our authors and Editorial Board members do, our Associate Editors represent the international community, and currently they are located in the USA, Canada, Sweden, and Israel.The turnaround time from first submission to decision for AJPEndo has been just under 20 days for the past three years! This feat was only achieved by the commitment and insight of the Associate Editors and the extremely responsive and knowledgeable reviewers, who do an amazing job of keeping the principles of fairness, timeliness, and helpfulness in their reviews. Our hats go off to them, first and foremost our nearly 120 Editorial Board members, but also our numerous Guest Reviewers who are called upon to help in this most valuable element of the scientific enterprise.I hope you all enjoy perusing the Reviews and Editorial Focus articles listed below, and I look forward to taking the Journal on to further heights in the upcoming months.This article has no references to display. Download PDF Back to Top Next FiguresReferencesRelatedInformationCited ByOn the shoulders of giantsCharles H. Lang, Editor-in-Chief1 July 2010 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 299, No. 1 More from this issue > Volume 298Issue 3March 2010Pages E375-E382 Copyright & PermissionsCopyright © 2010 the American Physiological Societyhttps://doi.org/10.1152/ajpendo.00770.2009History Published online 1 March 2010 Published in print 1 March 2010 Metrics

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