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THE PATHOLOGY OF SICKLE-CELL ANEMIA

1931; American Medical Association; Volume: 96; Issue: 20 Linguagem: Inglês

10.1001/jama.1931.02720460017005

2376-8118

Wallace M. Yater, Mario Mollari,

Blood groups and transfusion

The cause of the peculiar disease known as sickle-cell anemia is unknown. Clinical reports have been given by a number of authors (Herrick, 1 Huck, 2 Graham, 3 Mulherin and Houseal, 4 Sydenstricker, 5 Anderson, 6 Archibald, 7 Browne, 8 Cooley and Lee, 9 Dreyfoos, 10 Hamilton, 11 Alden, 12 Josephs, 13 Steinfield and Klauder, 14 Milliken, 15 Smith, 16 Wollstein and Kreidel, 17 Dolgopol and Stitt, 18 Fradkin, 19 Scriver and Waugh 20 ). The disease is limited almost exclusively to the Negro race and is familial and hereditary. There is a possibility that it may rarely occur in the Caucasian race (Castana, 21 Stewart, 22 Lawrence 23 ). It is estimated that about 7 per cent of Negroes have the sickle-cell trait; i. e., after anaerobic incubation the sickling of the erythrocytes occurs (Miyamoto and Korb, 24 Graham, 3 Cooley and Lee, 9 Brandau 25 ). Relatively few of these persons