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Clonidine reduces plasma melatonin levels

1986; Oxford University Press; Volume: 38; Issue: 7 Linguagem: Inglês

10.1111/j.2042-7158.1986.tb04639.x

2042-7158

Alfred J. Lewy, L.J. Siever, Thomas W. Uhde, Sanford P. Markey,

Asthma and respiratory diseases

Clonidine, an alpha-adrenoceptor agonist, reduces human plasma melatonin levels when administered intravenously at 2-3 micrograms kg-1 to sleeping volunteers. Measurement of plasma melatonin levels after administration of clonidine could be the basis for a clinical in-vivo test of alpha-adrenoceptors.