Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study
1996; Wiley; Volume: 21; Issue: 2 Linguagem: Inglês
10.1111/j.1365-2710.1996.tb00005.x
ISSN1365-2710
AutoresMasae Kuranari, Satoru Chiba, Yuka Ashikari, Yuki Kodama, Takeshi Sakata, Mirei Takeyama,
Tópico(s)Hemoglobinopathies and Related Disorders
ResumoJournal of Clinical Pharmacy and TherapeuticsVolume 21, Issue 2 p. 83-87 Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study M. Kuranari, Corresponding Author M. Kuranari Departments of Clinical Pharmacy, Oita Medical University, Hasama, Oita, 879-55, JapanM. Kuranari, Department of Clinical Pharmacy, Oita Medical University, Hasama-machi, Oita, 879-55, Japan.Search for more papers by this authorS. Chiba, S. Chiba *Internal Medicine 1, Oita Medical University, Hasama, Oita, 879-55, JapanSearch for more papers by this authorY. Ashikari, Y. Ashikari Departments of Clinical Pharmacy, Oita Medical University, Hasama, Oita, 879-55, JapanSearch for more papers by this authorY. Kodama, Y. Kodama Departments of Clinical Pharmacy, Oita Medical University, Hasama, Oita, 879-55, JapanSearch for more papers by this authorT. Sakata, T. Sakata *Internal Medicine 1, Oita Medical University, Hasama, Oita, 879-55, JapanSearch for more papers by this authorM. Takeyama, M. Takeyama Departments of Clinical Pharmacy, Oita Medical University, Hasama, Oita, 879-55, JapanSearch for more papers by this author M. Kuranari, Corresponding Author M. Kuranari Departments of Clinical Pharmacy, Oita Medical University, Hasama, Oita, 879-55, JapanM. Kuranari, Department of Clinical Pharmacy, Oita Medical University, Hasama-machi, Oita, 879-55, Japan.Search for more papers by this authorS. Chiba, S. Chiba *Internal Medicine 1, Oita Medical University, Hasama, Oita, 879-55, JapanSearch for more papers by this authorY. Ashikari, Y. Ashikari Departments of Clinical Pharmacy, Oita Medical University, Hasama, Oita, 879-55, JapanSearch for more papers by this authorY. Kodama, Y. Kodama Departments of Clinical Pharmacy, Oita Medical University, Hasama, Oita, 879-55, JapanSearch for more papers by this authorT. Sakata, T. Sakata *Internal Medicine 1, Oita Medical University, Hasama, Oita, 879-55, JapanSearch for more papers by this authorM. Takeyama, M. Takeyama Departments of Clinical Pharmacy, Oita Medical University, Hasama, Oita, 879-55, JapanSearch for more papers by this author First published: April 1996 https://doi.org/10.1111/j.1365-2710.1996.tb00005.xCitations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Summary The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36.3 kg/m2). The patient, who was given daily oral doses of 100 mg phenobarbital, 350 mg phenytoin, 800 mg valproic acid and 800 mg carbamazepine over 5 months was hospitalized for obesity treatment. The daily dosage of each drug was held constant during treatment of the obesity. Blood samples were taken five times. Weight reduction was 7 kg (7.5%) over 46 days. Estimation of the pharmacokinetic parameters in each drug was performed by Higuchi's Bayesian program, PEDA Pearson's correlation coefficient (r) between clearance and body weight was calculated for each drug. High positive correlations were found between clearance and body weight for phenytoin (r= 0.800) and valproic acid (r= 0.785), but not for phenobarbital (r= - 0.227) and carbamazepine (r= 0.152). Clearance of phenytoin and valproic acid may be potentially affected by small changes in body weight. Citing Literature Volume21, Issue2April 1996Pages 83-87 RelatedInformation
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