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Characterization of small intestinal transit time distribution in humans

1998; Elsevier BV; Volume: 171; Issue: 2 Linguagem: Inglês

10.1016/s0378-5173(98)00174-4

1873-3476

Lawrence X. Yu, Gordon L. Amidon,

Gastrointestinal motility and disorders

This report is aimed at characterizing small intestinal transit time distribution and presenting a slope-based method to determine compartmental transit and dispersion model parameters. The intradose, intrasubject, and intersubject means and variances were defined to examine small intestinal transit time distribution in individuals and populations. Equations were derived to determine the optimum number of compartments and the dispersion coefficient. It was found that the intra- or intersubject variance was significantly smaller than the intradose variance. The optimum number of compartments and the dispersion coefficient were estimated to be seven and 0.78 cm2/s, respectively, in agreement with the literature data.