Structure of the myelin sheath as a function of concentration of ions
1965; Elsevier BV; Volume: 102; Issue: 1 Linguagem: Inglês
10.1016/0926-6585(65)90219-0
ISSN1878-2574
Autores Tópico(s)Alzheimer's disease research and treatments
ResumoHomogenization of cerebral white matter or of peripheral nerve with 1 M NaCl caused the formation of micellar complexes bounded on the outside by a hydrophilic layer (“oil-in-water”). Homogenization of such tissues in 0.5 M CaCl2 caused the formation of lipophilic complexes. Histochemical experiments yielded comparable results. The implications of these observations for the study of the structure of myelin are discussed. Formation of oil-in-water and water-in-oil systems were associated respectively with the formation of aqueous channels or of oily pillars across the lamellae of myelin or across cell membrane layers. The possible formation of such channels in vivo as a result of localized changes in lipophilic-hydrophilic ratio may be used to explain a number of biological phenomena.
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