Long-term safety and efficacy are observed after implantation of Zotarolimus-Eluting Stent in real-world clinical practice
2008; European Association of Percutaneous Cardiovascular Interventions; Volume: 4; Issue: 3 Linguagem: Inglês
10.4244/eijv4i3a61
ISSN1969-6213
AutoresChi‐Hang Lee, Adrian F. Low, Eric Hong, Bee‐Choo Tai, I. Lim, Swee-Guan Teo, Yean‐Teng Lim, Huay Cheem Tan,
Tópico(s)Cardiac Valve Diseases and Treatments
ResumoZotarolimus-eluting stents (ZESs) have been shown to be safe and effective in randomised trials. We sought to report the clinical outcomes after implantation of ZES in real-world clinical practice.ZES have been approved for clinical use in Singapore since April 2005. Until December 31, 2007, a total of 219 patients had undergone implantation of ZES. After excluding 11 foreign patients with whom contact was lost, 208 patients (246 lesions, 305 stents) formed the study cohort. A high-proportion of diabetic patients (n=90, 43.3%) was included. Recommended dual antiplatelet therapy was at least 3 months (n=147) for patients treated before or 12 months (n=61) after January 2007. As of January 2008, the median follow-up duration was 19 months (range: 1 to 33 months). There were 10 (4.8%) deaths, including 7 (3.4%) cardiac deaths. Myocardial infarction occurred in 11 (5.3%) patients. The numbers of patients requiring target vessel revascularisation and target lesion revascularisation were 10 (4.8%) and 5 (2.4%) respectively. Using the ARC definition, there were two cases of definite stent thrombosis on days 7 and 17, and one case of probable stent thrombosis on day 15.In this real-world clinical experience, ZES was associated with a low incidence of adverse cardiac events at a medium follow-up of one and half years.
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