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High Performance Liquid Chromatography of an New Antineoplastic: (1-γ diethyl amino propyl amino)-5-methyl-dipyrido [4,3-b] [3,4-f] Indole (BD 40)

1983; Marcel Dekker; Volume: 6; Issue: 5 Linguagem: Inglês

10.1080/01483918308067016

2331-0413

David R. Blais, B. Gourmel, Michael T. Marty, C. Gisselbrecht, Émile Bisagni, M Boiron, C Dreux,

Synthesis and Biological Evaluation

Abstract An HPLC method for determination and quantitation of BD 40, a dipyrido indole derivative with potential antitumor activity is described. Samples obtained after ethyl acetate extraction have been chromatograph ed on a reverse phase column with a counter ion mobile phase. The molecule tested beeing detected by spectrofluorimetry and sensibility, specificity and reproduc ibility of the method are satisfactory enough to allow for pharmacokinetics studies in human.