Novel N-demethylation of ketolide: application to the solution phase parallel synthesis of N-desosaminyl-substituted ketolides using ion exchange resins
2002; Elsevier BV; Volume: 43; Issue: 23 Linguagem: Inglês
10.1016/s0040-4039(02)00746-3
ISSN1873-3581
AutoresAlexis Denis, Christelle Renou,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoA series of N-desosaminyl-substituted ketolides was synthesized in parallel by reductive amination of various aldehydes by a N-desmethyl-ketolide scaffold followed by a solid phase extraction protocol using ion exchange resins. In addition, we have demonstrated that diethyl azodicarboxylate (DEAD) can be used efficiently as a N-demethylating reagent to access to N-desmethyl-ketolides.
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