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New Sesquiterpene Hydroquinones from a Taiwanese Marine Sponge, Hippospongia m etachromia

2001; American Chemical Society; Volume: 64; Issue: 6 Linguagem: Inglês

10.1021/np000610c

1520-6025

Ya‐Ching Shen, Ching‐Yeu Chen, Yao‐Haur Kuo,

Marine Sponges and Natural Products

In addition to metachromins A (1), B (2), and E (9), two new sesquiterpene hydroquinones, hippochromins A and B (3, 4), were isolated from the Taiwanese marine sponge Hippospongia metachromia. The structures of 4−6 were established by extensive 2D NMR analysis. Metachromins A (1) and B (2), hippochromin A diacetate (5), and metachromin B monoacetate (8) exhibited potent cytotoxicities against human colon (COLO-205) and nasopharyngeal (KB) tumor cells, while compounds 6, 7, and 9 were inactive.