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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Clinical characteristics in subcortical ischemic white matter disease

2009; Thieme Medical Publishers (Germany); Volume: 67; Issue: 2a Linguagem: Inglês

10.1590/s0004-282x2009000200001

ISSN

1678-4227

Autores

Gilberto Sousa Alves, Carlos Eduardo de Oliveira Alves, Maria Elisa de Oliveira Lanna, Letice Ericeira-Valente, Felipe Kenji Sudo, Denise Madeira Moreira, Eliasz Engelhardt, Jerson Laks,

Tópico(s)

Acute Ischemic Stroke Management

Resumo

Vascular white matter lesions (WML) represent one of the main neuroimage findings in individuals older than 65 years and its clinical significance is still partially understood.To describe and analyze the clinical profile of a high severity sample with WML focusing on the frontal executive control.Outpatients (n=20) with high severity WML evaluated with magnetic resonance imaging were selected using the Fazekas scale.Most patients (n=17; 85%) presented an altered Trail Making Test ratio (section B/section A); on verbal fluency, 15 individuals (75%) performed below the cutoff score. Apathy (5.9 +/- 4.65) and depression (3.05+/-3.67) were frequent as assessed by the Neuropsychiatric Inventory. The impairment in functional activities strongly correlated with apathy (r=0.814, p<0.001) and verbal fluency (r=0.744, p<0.001).Executive dysfunction, apathy, and ratio depression were the main characteristics found. Extension of WML may have distinct impact on the clinical picture, but further studies with methodological adjustments are necessary to provide more definitive conclusions.

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