Enantioselective Total Synthesis of (+)-Eutypoxide B
1997; American Chemical Society; Volume: 62; Issue: 12 Linguagem: Inglês
10.1021/jo9617326
ISSN1520-6904
AutoresM. Teresa Barros, Christopher D. Maycock, M. Rita Ventura,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoThe enantioselective synthesis of (+)-eutypoxide B, a metabolite isolated from the culture medium of the fungus Eutypa lata, is described. Two highly stereoselective and efficient sequencial 1,4-additions to enone systems, derived from d-(−)-quinic acid, are the key to the synthesis. The synthesis of a diastereoisomer of (+)-eutypoxide B, was also accomplished.
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