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LPS/TLR4 signal transduction pathway

2008; Elsevier BV; Volume: 42; Issue: 2 Linguagem: Inglês

10.1016/j.cyto.2008.01.006

1096-0023

Yong‐Chen Lu, Wen‐Chen Yeh, Pamela S. Ohashi,

Antimicrobial Peptides and Activities

The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years. Here we review molecules involved in TLR4-mediated signaling, including players that are involved in the negative regulation of this important pathway.