Identification of phosphonic acids by capillary electrophoresis–ionspray mass spectrometry
1998; Elsevier BV; Volume: 825; Issue: 1 Linguagem: Inglês
10.1016/s0021-9673(98)00710-9
ISSN1873-3778
AutoresJ. P. Mercier, Patrick Chaimbault, Ph. Morin, M. Dreux, A. Tambuté,
Tópico(s)Microfluidic and Capillary Electrophoresis Applications
ResumoThe identification of alkylphosphonic acids in spiked tap water has been investigated by on-line capillary electrophoresis–UV spectrometry–mass spectrometry (CE–UV–MS) in negative-ion mode. The 5 mM sorbic acid–ammonia electrolyte (pH 6.5) allows simultaneous indirect UV and MS (ionspray) detection. Several parameters (electrolyte pH, make-up chemical composition and make-up flow-rate) have been optimized and 5 mg/l limit of detection has been reached for these analytes in selected ion monitoring MS detection. MS–MS detection has also been investigated to reach a low detection limit (100 μg/l) for alkyl alkylphosphonic acids in spiked tap water. The mass spectra of these compounds exhibit a very abundant negative ion, [M−H]− (MS) with characteristic fragmentation (MS–MS) of acids and monoesters. Quantitative analysis achieved with CE–UV shows good correlation coefficients and allows accurate quantification of the analytes.
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