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BIBTEX RIS

Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways

1997; Elsevier BV; Volume: 9; Issue: 5 Linguagem: Inglês

10.1016/s0955-0674(97)80122-6

ISSN

1879-0410

Autores

Angela I. M. Barth, Inke Näthke, W. James Nelson,

Tópico(s)

Kruppel-like factors research

Resumo

Cadherins play important roles in cell-cell adhesion during tissue differentiation. Cadherins are linked to the actin cytoskeleton by catenins (beta-catenin/armadillo, plakoglobin, and alpha-catenin). Recent results show that beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis.

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