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BIBTEX RIS

Rhodium-Catalyzed C−C Bond Cleavage: Construction of Acyclic Methyl Substituted Quaternary Stereogenic Centers

2010; American Chemical Society; Volume: 132; Issue: 15 Linguagem: Inglês

10.1021/ja101469t

ISSN

1943-2984

Autores

Tobias Seiser, Nicolai Cramer,

Tópico(s)

Carbon dioxide utilization in catalysis

Resumo

A rhodium-catalyzed enantioselective insertion into the C-C bond of tert-cyclobutanols and subsequent proto-demetalation provides access to methyl substituted quaternary stereogenic centers in excellent yields and enantioselectivities. The reaction was used for a synthesis of (S)-4-ethyl-4-methyl-octane, the simplest saturated hydrocarbon with a quaternary stereogenic center.

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