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Microbial reduction of α-acetyl-γ-butyrolactone

2006; Elsevier BV; Volume: 17; Issue: 6 Linguagem: Inglês

10.1016/j.tetasy.2006.03.015

1362-511X

Joyce Benzaquem Ribeiro, Livia Maria Andrade de Sousa, Mariana da Volta Soares, Maria da Conceição Klaus V. Ramos, Francisco Radler de Aquino Neto, Carlos Alberto Manssour Fraga, Selma Gomes Ferreira Leite, Yraima Cordeiro, Octávio Augusto Ceva Antunes,

Biochemical Acid Research Studies

Isomers of α-1′-hydroxyethyl-γ-butyrolactone can be considered as potential GHB receptor ligands designed by the molecular hybridization of GLB 2 and GHV 4. Using Aspergillus niger, Geotrichum candidum, and Kluyveromyces marxianus, it was possible to obtain (+)-(3R,1′S)-α-1′-hydroxyethyl-γ-butyrolactone in good to excellent conversions, diastereoisomeric and enantiomeric excesses. The corresponding enantiomer, (−)-(3S,1′S)-α-1′-hydroxyethyl-γ-butyrolactone was also produced in good conversion, and diastereoisomeric and enantiomeric excesses using Hansenula sp.