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Myosin Phosphorylation and the Cross-Bridge Cycle in Arterial Smooth Muscle

1981; American Association for the Advancement of Science; Volume: 211; Issue: 4481 Linguagem: Inglês

10.1126/science.6893872

1095-9203

Patrick F. Dillon, Mark O. Aksoy, Steven P. Driska, Richard A. Murphy,

Cardiovascular Function and Risk Factors

Phosphorylation of the 20,000-dalton light chain of myosin is closely correlated with cross-bridge cycling in arterial smooth muscle. Evidence is presented that dephosphorylation can produce an attached, noncycling cross-bridge (latch-bridge) which is responsible for the high economy of force maintenance in this tissue.