Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Alkaloids, Amides and Antispasmodic Activity of Zanthoxylum hyemale

2002; Thieme Medical Publishers (Germany); Volume: 68; Issue: 6 Linguagem: Inglês

10.1055/s-2002-32550

1439-0221

Neusa Fernandes de Moura, Ademir F. Morel, Emilia C. Dessoy, Nilo Zanatta, Marilise Escobar Bürger, Neusa Ahlert, Gerusa Paz Porto, Bernardo Baldisserotto,

Chemical synthesis and alkaloids

Two quinoline alkaloids, (-)-R-geilbalansine (1) and hyemaline (2), as well as aromatic amide, N-[2-(3,4-dimethoxyphenyl)-2-methoxyethyl)-2-methoxyethyl]benzamide (O-methylbalsamide) (3), were isolated as new natural products from the stem barks of Zanthoxylum hyemale, together with seven known compounds. Their structures were determined on the basis of spectroscopic data (IR, 1H- and 13C-NMR, MS). In addition, the antispasmodic activity of the crude extract of Z. hyemale and three other more abundant isolated compounds (4, 5 and 10) were studied in two different antispasmodic test models on isolated rat ileum and only the crude ethanolic extract presented antispasmodic activity.