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Pulmonary Complications of Sickle Cell Disease

2008; Massachusetts Medical Society; Volume: 359; Issue: 21 Linguagem: Inglês

10.1056/nejmra0804411

1533-4406

Mark T. Gladwin, Elliott Vichinsky,

Heme Oxygenase-1 and Carbon Monoxide

This review presents evidence for two overlapping yet distinctive clinical types of sickle cell disease. The basis of one is the vaso-occlusive crisis; the other is the consequence of intravascular hemolysis. The authors focus on the acute vaso-occlusive crisis, the acute chest syndrome, and pulmonary hypertension, all common complications of sickle cell disease.