A close family resemblance: the importance of structure in understanding cytochromes P450
1998; Elsevier BV; Volume: 6; Issue: 9 Linguagem: Inglês
10.1016/s0969-2126(98)00109-9
ISSN1878-4186
AutoresJulian A. Peterson, Sandra E. Graham,
Tópico(s)Cancer Treatment and Pharmacology
ResumoAbstract Cytochromes P450 comprise a very large superfamily of hemeproteins which generally monooxygenate hydrophobic compounds. P450s appear to have a common conserved structural core, yet are variable in regions involved in substrate recognition and binding, and in redox-partner binding. These differences can be identified by an analysis in which structural alignments and homology models are used to compare the various classes and families of P450s.
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