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New microbiological catalytic accesses to (S)-fluoxetine

2005; Elsevier BV; Volume: 6; Issue: 2 Linguagem: Inglês

10.1016/j.catcom.2004.12.001

1873-3905

Joyce Benzaquem Ribeiro, Maria da Conceição Klaus V. Ramos, Francisco Radler de Aquino Neto, Selma Gomes Ferreira Leite, Octávio Augusto Ceva Antunes,

Analytical Chemistry and Chromatography

Saccharomyces cerevisiae, Hansenula sp., Dekera sp. and Kluyveromyces marxianus free and immobilized and free Geotrichum sp. have been used in the reduction of ethyl benzoylacetate yielding, in up to 99% ees, ethyl (S)-3-hydroxi-3-phenylpropionate, a suitable intermediate for the production of fluoxetine.