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Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

2009; Nature Portfolio; Volume: 41; Issue: 8 Linguagem: Inglês

10.1038/ng.416

1546-1718

Emelia J. Benjamin, Kenneth Rice, Dan E. Arking, Arne Pfeufer, Charlotte van Noord, Albert V. Smith, Renate B. Schnabel, Joshua C. Bis, Eric Boerwinkle, Moritz F. Sinner, Abbas Dehghan, Steven A. Lubitz, Ralph B. D’Agostino, Thomas Lumley, Georg Ehret, Jan Heeringa, Thor Aspelund, Christopher Newton‐Cheh, Martin G. Larson, Kristin D. Marciante, Elsayed Z. Soliman, Fernando Rivadeneira, Thomas J. Wang, Guðný Eiríksdóttir, Daniel Levy, Bruce M. Psaty, Man Li, Alanna M. Chamberlain, Albert Hofman, Ramachandran S. Vasan, Tamara B. Harris, Jerome I. Rotter, W.H. Linda Kao, Sunil Agarwal, Bruno H. Stricker, Ke Wang, Lenore J. Launer, Nicholas L. Smith, Aravinda Chakravarti, André G. Uitterlinden, Philip A. Wolf, Nona Sotoodehnia, Anna Köttgen, Cornelia M. van Duijn, Thomas Meitinger, Martina Mueller, Siegfried Perz, Gerhard Steinbeck, H‐Erich Wichmann, Kathryn L. Lunetta, Susan R. Heckbert, Vilmundur Guðnason, Álvaro Alonso, Stefan Kääb, Patrick T. Ellinor, Jacqueline C.M. Witteman,

Blood Coagulation and Thrombosis Mechanisms

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).