The effect of O-(β-hydroxyethyl) rutoside on platelet intermediary metabolism in normal and streptozotocin diabetic rats
1974; Elsevier BV; Volume: 23; Issue: 11 Linguagem: Inglês
10.1016/0006-2952(74)90371-2
ISSN1873-2968
AutoresR. A. Paterson, H. D. Heath, Tanya Cranfield,
Tópico(s)Advanced Glycation End Products research
ResumoOn the basis of measurements of platelet glycolytic intermediates from glycogen to pyruvate, washed platelet suspensions from rats with diabetes induced 3–7 months previously with streptozotocin showed a 60 per cent reduction in fructose-6-phosphate and 200 per cent increases in fructose-1,6-diphosphate, 3-phosphoglycerate and pyruvate when compared to normal. These results coupled with increases in the products of glycolysis during aggregation induced by 5μM ADP, suggested increased glycolytic activity in diabetic rat platelets. O-(β-hydroxyethyl)-rutosides (50 mg s.c./100 g for 3 days) reduced glycolytic intermediates in platelets from both normal and diabetic rats to about the same level. ATP and glycogen levels were also reduced. An increase in platelet glycolytic activity may be connected with increased platelet adhesiveness and ease of ADP-induced aggregation reported in humans with deteriorating diabetic microangiopathy.
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