677 Hepatic gene expression analysis in acute alcoholic hepatitis identifies nadph oxidase and GRO-α as potential therapeutical targets
2006; Elsevier BV; Volume: 44; Linguagem: Inglês
10.1016/s0168-8278(06)80677-x
ISSN1600-0641
AutoresJ. Colmenerol, Ramón Bataller, Pau Sancho‐Bru, Juan Carlos García–Pagán, Rosa Miquel, María Perla Moreno Arroyo, J. Bosch, Vicente Arroyo, Joan Caballería, Pere Ginés,
Tópico(s)Eicosanoids and Hypertension Pharmacology
ResumoPOSTERSinfection, matched for sex and age with 280 randomly selected subjects without SLD belonging to the same cohort.All the subjects underwent a detailed clinical, laboratory and anthropometrical evaluation.FL was diagnosed by ultrasonography (US) and alcohol intake by a seven-day diary.Univariable and multivariable logistic regression models were used to identify risk factors for FL vs. normal liver.Results: Male gender, age, GGT, body mass index, waist circumference, triglycerides and insulin were independent significant risk factors for FL in the final model while ethanol intake, ALT, the sum of 4 sldnfold thicknesses and glucose were not.After removal of the non-significant predictors, the accuracy of the model, as determined by the area under the ROC curve, was 0.82 (95%CI: 0.78 0.85, p 3.0 (positive likelihood ratio 4.4) and rule out FL with a score of 1.0 (negative likelihood ratio 0.2).Conclusions: FLI may be useful to the GP in clinical practice, particularly when access to US is not easily available.
Referência(s)