Experimental superficial candidiasis on tissue models
2010; Wiley; Linguagem: Inglês
10.1111/j.1439-0507.2010.01879.x
ISSN1439-0507
AutoresJ. A. M. S. Jayatilake, L. P. Samaranayake,
Tópico(s)Infectious Diseases and Mycology
ResumoMycosesVolume 53, Issue 4 p. 285-295 Experimental superficial candidiasis on tissue models J. A. M. S. Jayatilake, J. A. M. S. Jayatilake Division of Microbiology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri LankaSearch for more papers by this authorL. P. Samaranayake, L. P. Samaranayake Oral Biosciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this author J. A. M. S. Jayatilake, J. A. M. S. Jayatilake Division of Microbiology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri LankaSearch for more papers by this authorL. P. Samaranayake, L. P. Samaranayake Oral Biosciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this author First published: 09 June 2010 https://doi.org/10.1111/j.1439-0507.2010.01879.xCitations: 1 Dr J. A. M. S. Jayatilake, Division of Microbiology, Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.Tel.: +94 0812 397 246. Fax: +94 0812 388 948.E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary Candida species are common pathogens causing superficial mycoses primarily affecting the mucosa and the skin in humans. Crucial steps during pathogenesis of superficial candidiasis comprise fungal adhesion, colonisation and subsequent penetration of the respective tissues. Exploring these pathological events and perhaps fungal and tissue responses towards drug treatment is imperative in the management of this infection. Unfortunately, pathological biopsies of superficial candidiasis do not exhibit the early changes in the host–pathogen interaction as the tissues are already invaded by the fungi. In vivo experimental assessments of pathological processes of superficial candidiasis are also limited because of the difficulties in providing reproducible and comparable conditions in the host environment. Conversely, in vitro models have helped studying fungal–host interactions under more defined and controlled conditions. Some common in vitro models used to simulate superficial candidiasis are chick chorioallantoic membrane, mucosal explants and single layer or multiple layer cell cultures. 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