Ceratinamides A and B: New antifouling dibromotyrosine derivatives from the marine sponge Pseudoceratina purpurea
1996; Elsevier BV; Volume: 52; Issue: 24 Linguagem: Inglês
10.1016/0040-4020(96)00387-0
ISSN1464-5416
AutoresSachiko Tsukamoto, Haruko Kato, Hiroshi Hirota, Nobuhiro Fusetani,
Tópico(s)Marine Biology and Environmental Chemistry
ResumoCeratinamides A and B (1 and 2), new bromotyrosine derivatives, have been isolated from the marine sponge Pseudoceratina purpurea, along with the known psammaplysins A (3) and E (4), ceratinamine (5), moloka'iamine (6), pseudoceratidine (7), and 4,5-dibromopyrrole-2-carbamide (8). Their structures were elucidated on the basis of spectral data. Compounds 1–7 inhibited larval settlement and metamorphosis of the barnacle Balanus amphitrite with ED50 values of 0.10–8.0 μg/mL, while compounds 3 and 8 induced larval metamorphosis of the ascidian Halocynthia roretzi at concentrations of 1.2 and 25 μg/mL, respectively. Compounds 5 and 6 also showed cytotoxicity against P388 murine leukemia cells with IC50 values of 3.4 and 2.1 μg/mL, respectively; 7 was antibacterial against Flavobacterium marinotypicum.
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