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Different MOG35–55 concentrations induce distinguishable inflammation through early regulatory response by IL-10 and TGF-β in mice CNS despite unchanged clinical course

2015; Elsevier BV; Volume: 293; Issue: 2 Linguagem: Inglês

10.1016/j.cellimm.2014.12.009

1090-2163

Alyria Teixeira Dias, Sandra B. R. Castro, Caio César de Souza Alves, Felipe Pereira Mesquita, Nathália Stela Visoná de Figueiredo, Marcilene Gomes Evangelista, Maria Christina Marques Nogueira Castañon, María A. Juliano, Ana Paula Ferreira,

Immune cells in cancer

Multiple sclerosis (MS) shows distinct clinical courses. Experimental autoimmune encephalomyelitis (EAE), a model to study multiple sclerosis, can be induced by different protocols, which show distinct cytokine and antibody production. The factors involved in this heterogeneity remain unclear. The relevance of MOG concentration in triggering a regulatory response in the chronic model of EAE is imprecise. The aim of this study was investigate if 100 or 300 μg of MOG(35-55) could induce different EAE profiles. Modifications in the concentration of MOG were able to change the patterns of chemokines, cytokines, percentage of cells, inflammatory infiltrate and the development of a regulatory response. However, these changes were unable to modify the intensity of response, which explains the chronic progression of the disease in both concentrations. The results presented in this study contribute to understanding the intricate mechanisms that trigger EAE and provide insights into the pathogenesis of various forms of MS.