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Body weight gain and serum leptin levels of non-overweight and overweight/obese pregnant women

2013; International Scientific Information Inc.; Volume: 19; Linguagem: Inglês

10.12659/msm.884027

1643-3750

Didier Silveira Castellano Filho, José Otávio do Amaral Corrêa, Plínio dos Santos Ramos, Marina de Oliveira Montessi, Beatriz Julião Vieira Aarestrup, Fernando Monteiro Aarestrup,

Adipose Tissue and Metabolism

Background:Our objective was to evaluate changes in serum leptin levels during pregnancy in overweight/obese and nonobese women and to assess total and percent weight gain during pregnancy as possible factors that influence leptin levels. Material/Methods:In a prospective study of 42 low-risk pregnant women receiving prenatal care, we assessed serum leptin levels at gestational weeks 9-12, 25-28, and 34-37.Based on their pre-pregnancy body mass indices (BMIs), the cohort was divided into: non-overweight (BMI <25 kg/m 2 ) and overweight/obese (BMI ≥25 kg/m 2 ) subjects. Results:We found a progressive increase in maternal weight gain during pregnancy in both groups.There was also a progressive increase in leptin levels in the 2 strata; however, the increase was significantly higher in the nonoverweight patient group.We found that non-overweight pregnant women had a noticeably larger total weight gain.When analyzing the percent weight gain during pregnancy compared to the pre-pregnancy weight, the non-overweight group had a significantly greater percent weight gain than the overweight/obese group. Conclusions:Our results suggest that the greater increase in leptin levels in non-overweight pregnant women can be explained by the higher percent weight gain in this group compared to overweight/obese women.These findings suggest that controlling the percent weight gain may be an important preventive measure when controlling leptin levels during pregnancy and subsequent medical complications.