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Therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes for oral cancer in the hamster cheek pouch model

2014; National Academy of Sciences; Volume: 111; Issue: 45 Linguagem: Inglês

10.1073/pnas.1410865111

1091-6490

Elisa M. Heber, M. Frederick Hawthorne, Peter J. Kueffer, Marcela A. Garabalino, Silvia I. Thorp, Emiliano C. C. Pozzi, Andrea Monti Hughes, Charles A. Maitz, Satish S. Jalisatgi, David W. Nigg, Paula Curotto, Verónica A. Trivillin, Amanda E. Schwint,

Boron and Carbon Nanomaterials Research

Significance Boron neutron capture therapy (BNCT) for cancer is based on the selective uptake of 10 B target compounds by tumor cells followed by neutron irradiation. The capture reaction between 10 B atoms and neutrons gives rise to short-range particles, which are highly effective in producing cell damage. Thus, BNCT is designed to damage tumor cells and preserve healthy cells. The boron carrier used is pivotal to the success of BNCT. The present study describes the therapeutic success of BNCT mediated by MAC-TAC liposomes, K[ nido -7-CH 3 (CH 2 ) 15 -7,8-C 2 B 9 H 11 ] (MAC) in the bilayer membrane and encapsulating the hydrophilic species Na 3 [ ae -B 20 H 17 NH 3 ] (TAC) in the aqueous core, using the hamster cheek pouch oral cancer model. A sustained tumor response of 70–88% was associated with only mild mucositis in dose-limiting precancerous tissue.