Single Nucleotide Polymorphisms and the Likelihood of Prostate Cancer at a Given Prostate Specific Antigen Level
2009; Lippincott Williams & Wilkins; Volume: 182; Issue: 1 Linguagem: Inglês
10.1016/j.juro.2009.02.126
ISSN1527-3792
AutoresStacy Loeb, H. Ballentine Carter, Patrick C. Walsh, William B. Isaacs, Anna Kettermann, Toshiko Tanaka, Luigi Ferrucci, E. Jeffrey Metter,
Tópico(s)Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
ResumoNo AccessJournal of UrologyAdult Urology1 Jul 2009Single Nucleotide Polymorphisms and the Likelihood of Prostate Cancer at a Given Prostate Specific Antigen Level Stacy Loeb, H. Ballentine Carter, Patrick C. Walsh, William B. Isaacs, Anna Kettermann, Toshiko Tanaka, Luigi Ferrucci, and E. Jeffrey Metter Stacy LoebStacy Loeb James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland , H. Ballentine CarterH. Ballentine Carter James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland , Patrick C. WalshPatrick C. Walsh James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland , William B. IsaacsWilliam B. Isaacs James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland , Anna KettermannAnna Kettermann James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland , Toshiko TanakaToshiko Tanaka National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland , Luigi FerrucciLuigi Ferrucci National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland , and E. Jeffrey MetterE. Jeffrey Metter National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland View All Author Informationhttps://doi.org/10.1016/j.juro.2009.02.126AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels. Materials and Methods: We examined associations between single nucleotide polymorphisms on chromosomes 10 and 19 (previously shown to be associated with prostate specific antigen) with prostate specific antigen and prostate cancer in 505 men from the Baltimore Longitudinal Study of Aging. Results: In a model with age and date the risk ratio for prostate cancer was 1.18 (95% CI 1.13–1.23) per unit increase in prostate specific antigen. Including the interaction between alleles and prostate specific antigen significantly altered the risk ratio for prostate cancer (Cox proportional hazards p <0.001). Specifically prostate cancer risk per unit increase in prostate specific antigen was significantly different in carriers than in noncarriers of a minor allele (1.28 vs 1.10, respectively, Cox proportional hazards p <0.001), whereas men with a minor allele had a significantly higher risk of prostate cancer at prostate specific antigen levels greater than 6 ng/ml. Conclusions: Our data suggest that genotype influences the risk of prostate cancer per unit increase in prostate specific antigen. Prostate cancer risk stratification using prostate specific antigen and genotype could improve prostate specific antigen test performance. References 1 : A common variant associated with prostate cancer in European and African populations. Nat Genet2006; 38: 652. Google Scholar 2 : Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24. Cancer Epidemiol Biomarkers Prev2007; 16: 809. Google Scholar 3 : Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet2007; 39: 977. Google Scholar 4 : Cumulative association of five genetic variants with prostate cancer. N Engl J Med2008; 358: 910. Google Scholar 5 : Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet2008; 40: 316. Google Scholar 6 : The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2. Oncogene2007; 26: 4590. Google Scholar 7 : Operating characteristics of prostate-specific antigen in men with an initial PSA level of 3.0 ng/ml or lower. JAMA2005; 294: 66. Google Scholar 8 : Longitudinal evaluation of prostate-specific antigen levels in men with and without prostate disease. JAMA1992; 267: 2215. Crossref, Medline, Google Scholar 9 : Association between polymorphisms in the prostate-specific antigen (PSA) promoter and release of PSA. 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Link, Google Scholar © 2009 by American Urological AssociationFiguresReferencesRelatedDetailsCited byTaneja S (2015) Re: Do Environmental Factors Modify the Genetic Risk of Prostate Cancer?Journal of Urology, VOL. 193, NO. 5, (1540-1540), Online publication date: 1-May-2015.Helfand B, Loeb S, Hu Q, Cooper P, Roehl K, McGuire B, Baumann N and Catalona W (2012) Personalized Prostate Specific Antigen Testing Using Genetic Variants May Reduce Unnecessary Prostate BiopsiesJournal of Urology, VOL. 189, NO. 5, (1697-1701), Online publication date: 1-May-2013.Coetzee G (2011) The Usefulness of Prostate Cancer Genome-Wide Association StudiesJournal of Urology, VOL. 187, NO. 1, (9-10), Online publication date: 1-Jan-2012.Walsh P (2011) Re: Genetic Correction of PSA Values Using Sequence Variants Associated With PSA LevelsJournal of Urology, VOL. 186, NO. 1, (103-104), Online publication date: 1-Jul-2011. Volume 182Issue 1July 2009Page: 101-105 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordspolymorphismprostatic neoplasmsgeneticsprostate-specific antigensingle nucleotidemass screeningMetricsAuthor Information Stacy Loeb James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author H. Ballentine Carter James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Patrick C. Walsh James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author William B. Isaacs James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Anna Kettermann James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Toshiko Tanaka National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland More articles by this author Luigi Ferrucci National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland More articles by this author E. Jeffrey Metter National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland More articles by this author Expand All Advertisement PDF downloadLoading ...
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