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Calcium and contraction of glycerinated muscle fibers I. Removal of calcium with “granules” or a metal-binding resin

1962; Elsevier BV; Volume: 65; Issue: 1 Linguagem: Inglês

10.1016/0006-3002(62)90150-6

1878-2434

F. Norman Briggs, Regis King,

Muscle activation and electromyography studies

Attempts to discover if there is a concentration of calcium ion critical for tension generation in glycerinated fibers have been completely unsuccessful. The rate at which maximal tension generation was reached and the magnitude of the tension were unaffected by reducing calcium ion to concentrations calculated to be as low as 6.9·10−10M. The hypothesis that the small granule fraction of Marsh factor inhibits tension generation by simple withdrawal of calcium has been made improbable by the observation that the divalent metal-chelating resin Chelex-100, though 10 times more effective than granules in decreasing calcium ion, had only slight effects on tension generation when compared to the effects of the granules. These data indicate the necessity of postulating that the inhibition of tension generation produced by granules must be the result of an inhibitor formed and/or released by the granules.