Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: Synthesis, characterization, and DNA cleavage
2005; Elsevier BV; Volume: 33; Issue: 5 Linguagem: Inglês
10.1016/j.bioorg.2005.07.003
ISSN1090-2120
AutoresWei Peng, Peiyan Liu, Ning Jiang, Honghui Lin, Guolin Zhang, Yi Liu, Xiao‐Qi Yu,
Tópico(s)Molecular Sensors and Ion Detection
ResumoDinuclear macrocyclic polyamine zinc(II) complexes, which have two cyclen groups linked by flexible spacers, have been synthesized as DNA cleavage agents. The structures of these new dinuclear complexes are consistent with the data obtained from elemental analysis, MS and 1H NMR spectroscopy. The catalytic activity of these dinuclear complexes on DNA cleavage was studied. The results showed that the dinuclear zinc(II) complexes can catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA) (Form I) under physiological conditions to produce selectively nicked DNA (Form II).
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