Angiotensin II inhibits the release of [3H]acetylcholine from rat entorhinal cortex in vitro
1989; Elsevier BV; Volume: 491; Issue: 1 Linguagem: Inglês
10.1016/0006-8993(89)90095-4
ISSN1872-6240
AutoresJanine M. Barnes, Nicholas M. Barnes, B. Costall, Zola P. Horovitz, R.J. Naylor,
Tópico(s)Renin-Angiotensin System Studies
ResumoThe effects of angiotensin I and II on basal potassium-induced release of [3H]acetylcholine were investigated in slices of rat entorhinal cortex. Potassium (10–25 mM) produced a concentration-dependent increase in the release of [3H]acetylcholine in the presence of extracellular calcium. Angiotensin II (10−9-10−5 M) (but not angiotensin I) reduced the potassium-induced release of [3H]acetylcholine in a concentration-related manner to 60% of control levels, but did not effect basal tritium release. The effect of angiotensin II was antagonised by [1-sarcosine, 8-threonine] angiotensin II, an angiotensin II receptor antagonist, but not by agents acting on α- and β-adrenoceptors, muscarinic, nicotinic, histamine or 5-hydroxytryptamine receptors nor by the angiotensin converting enzyme (ACE) inhibitor SQ 29852. The results indicate that angiotensin II acting via an angiotensin II receptor can inhibit the release of [3H]acetylcholine in slices of the rat entorhinal cortex. It is hypothesised that the ability of ACE inhibitors to facilitate cognitive processes may be related to a reduced availability of angiotensin II.
Referência(s)