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Nanopore-Based Fourth-Generation DNA Sequencing Technology

2015; Elsevier BV; Volume: 13; Issue: 1 Linguagem: Inglês

10.1016/j.gpb.2015.01.009

2210-3244

Yanxiao Feng, Yuechuan Zhang, Cuifeng Ying, Deqiang Wang, Chunlei Du,

Ion-surface interactions and analysis

Abstract Nanopore-based sequencers, as the fourth-generation DNA sequencing technology, have the potential to quickly and reliably sequence the entire human genome for less than $1000, and possibly for even less than $100. The single-molecule techniques used by this technology allow us to further study the interaction between DNA and protein, as well as between protein and protein. Nanopore analysis opens a new door to molecular biology investigation at the single-molecule scale. In this article, we have reviewed academic achievements in nanopore technology from the past as well as the latest advances, including both biological and solid-state nanopores, and discussed their recent and potential applications.