Portal de Periódicos da CAPES

Evaluation of Ischemic Damage in the Skeletal Muscle with the Use of Electrical Properties

1998; Elsevier BV; Volume: 80; Issue: 2 Linguagem: Inglês

10.1006/jsre.1998.5477

1095-8673

Masatoshi Hayashi, Hajime Hirose, Eisaku Sasaki, Shoshi Senga, Shinji Murakawa, Yoshio Mori, Yasunobu Furusawa, Michiya Banodo,

Cardiac Arrest and Resuscitation

We performed experimental and clinical studies with measurement of electrical character in the skeletal muscle to assess ischemic damage and reperfusion injury in lower limbs. In 14 dogs, the bilateral hind limbs were squeezed at the inguinal region to make ischemia and they were reperfused after various intervals. Conductivity (G) of the skeletal muscles in hind limbs was measured with an LCR meter, which is an impedance analyzer. Change ofGfrom 0 to 3 h of reperfusion (Δ3G) was calculated.Gwas decreased during ischemia and increased after reperfusion. In those whose Δ3Gas more than 2.1 mS/cm, serum creatine kinase and aldolase at 10 h after reperfusion were correlated significantly (P< 0.01) to Δ3G. In patients with an abdominal aortic aneurysm (N= 3), arteriosclerosis obliterans (N= 1), or acute arterial occlusion (AAO,N= 1),Gof lower extremities was measured from arterial clamp to declamp. Conductivity markedly increased after reperfusion and serum creatine kinase was the highest in the patient with AAO. We suggested that measurement ofGmay provide monitoring of ischemic and reperfused phase injury in the skeletal muscle and may be applicable to prediction of the skeletal muscular reperfusion injury.