Voltar
Revisão Acesso aberto Revisado por pares
BIBTEX RIS

GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

2007; Wiley; Volume: 29; Issue: 4 Linguagem: Inglês

10.1002/bies.20558

ISSN

1521-1878

Autores

Xosé R. Bustelo, Vincent Sauzeau, Inmaculada M. Berenjeno,

Tópico(s)

Retinal Development and Disorders

Resumo

Abstract Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family. BioEssays 29:356–370, 2007. © 2007 Wiley Periodicals, Inc.

Referência(s)