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Dopamine infusion: A possible cause of undiagnosed congenital hypothyroidism in preterm infants

2006; Lippincott Williams & Wilkins; Volume: 7; Issue: 3 Linguagem: Inglês

10.1097/01.pcc.0000216680.22950.d9

1947-3893

Luca Filippi, Marco Pezzati, Alessandra Cecchi, Chiara Poggi,

Neonatal Respiratory Health Research

Objective: To describe the possibility that dopamine infusion can prevent early diagnosis of congenital hypothyroidism. Design: Case report. Setting: Medical neonatal intensive care unit of a tertiary academic medical center. Patients: We report four preterm newborns affected by transient primary congenital hypothyroidism who showed low serum thyroxine and normal thyroid-stimulating hormone concentrations on primary screening performed during treatment with dopamine. Interventions: Thyroid reevaluation screening after dopamine discontinuation. Measurements and Main Results: Thyroid reevaluation showed elevated thyroid-stimulating hormone levels. Conclusion: We emphasize that dopamine capacity to suppress thyroid-stimulating hormone could prevent early diagnosis of congenital hypothyroidism. We suggest all newborns to be tested simultaneously for thyroid-stimulating hormone and thyroxine values at primary screening. A reevaluation of thyroid hormones after dopamine discontinuation is advisable in patients treated with dopamine.