Tomatidine inhibits iNOS and COX‐2 through suppression of NF‐κB and JNK pathways in LPS‐stimulated mouse macrophages
2008; Wiley; Volume: 582; Issue: 16 Linguagem: Inglês
10.1016/j.febslet.2008.05.049
ISSN1873-3468
Autores Tópico(s)Phytochemical Studies and Bioactivities
ResumoWe use the LPS‐stimulated macrophage as a model of inflammation to investigate the anti‐inflammatory effects of tomatidine and solasodine, whose structures resemble glucocorticoids. We found that tomatidine exhibited a more potent anti‐inflammatory effect than solasodine. Tomatidine could decrease inducible nitric oxide synthase and cyclooxygenase‐2 expression through suppression of I‐κBα phosphorylation, NF‐κB nuclear translocation and JNK activation, which in turn inhibits c‐jun phosphorylation and Oct‐2 expression. Here, we demonstrate that tomatidine acts as an anti‐inflammatory agent by blocking NF‐κB and JNK signaling, and may possibly be developed as a useful agent for the chemoprevention of cancer or inflammatory diseases.
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