Quantification of skin-colour changes induced by topical corticosteroid preparations using the Minolta Chroma Meter
1991; Oxford University Press; Volume: 124; Issue: 3 Linguagem: Inglês
10.1111/j.1365-2133.1991.tb00571.x
ISSN1365-2133
AutoresCatherine Queille‐Roussel, Michel Poncet, Hans Schaefer,
Tópico(s)Dermatology and Skin Diseases
ResumoBritish Journal of DermatologyVolume 124, Issue 3 p. 264-270 Quantification of skin-colour changes induced by topical corticosteroid preparations using the Minolta Chroma Meter CATHERINE QUEILLE-ROUSSEL, Corresponding Author CATHERINE QUEILLE-ROUSSEL Centre International de Recherches Dermatologiques Galderma (CIRD Galderma), Sophia Antipolis, 06565 Valbonne Cedex, France Centre de Pharmacologie Appliquée à la Dermatologie (CPCAD), Hopital Pasteur, 06000 Nice, FranceDr C. Queille-Roussel, CIRD Galderma, Sophia, Sophia Antipolis, 06565 Valbonne Cedex, FranceSearch for more papers by this authorM. PONCET, M. PONCET Centre International de Recherches Dermatologiques Galderma (CIRD Galderma), Sophia Antipolis, 06565 Valbonne Cedex, France Centre de Pharmacologie Appliquée à la Dermatologie (CPCAD), Hopital Pasteur, 06000 Nice, FranceSearch for more papers by this authorH. SCHAEFER, H. SCHAEFER Centre International de Recherches Dermatologiques Galderma (CIRD Galderma), Sophia Antipolis, 06565 Valbonne Cedex, France Centre de Pharmacologie Appliquée à la Dermatologie (CPCAD), Hopital Pasteur, 06000 Nice, FranceSearch for more papers by this author CATHERINE QUEILLE-ROUSSEL, Corresponding Author CATHERINE QUEILLE-ROUSSEL Centre International de Recherches Dermatologiques Galderma (CIRD Galderma), Sophia Antipolis, 06565 Valbonne Cedex, France Centre de Pharmacologie Appliquée à la Dermatologie (CPCAD), Hopital Pasteur, 06000 Nice, FranceDr C. Queille-Roussel, CIRD Galderma, Sophia, Sophia Antipolis, 06565 Valbonne Cedex, FranceSearch for more papers by this authorM. PONCET, M. PONCET Centre International de Recherches Dermatologiques Galderma (CIRD Galderma), Sophia Antipolis, 06565 Valbonne Cedex, France Centre de Pharmacologie Appliquée à la Dermatologie (CPCAD), Hopital Pasteur, 06000 Nice, FranceSearch for more papers by this authorH. SCHAEFER, H. SCHAEFER Centre International de Recherches Dermatologiques Galderma (CIRD Galderma), Sophia Antipolis, 06565 Valbonne Cedex, France Centre de Pharmacologie Appliquée à la Dermatologie (CPCAD), Hopital Pasteur, 06000 Nice, FranceSearch for more papers by this author First published: March 1991 https://doi.org/10.1111/j.1365-2133.1991.tb00571.xCitations: 70AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Summary The Minolta tri-stimulus colorimeter CR-200 was used to quantify the blanching effect of topical corticosteroids in a non-occluded vasoconstriction test. To investigate the influence of time on variations in colorimetric parameters, an initial series of measurements was performed on Day 1 on six predetermined sites on the ventral surface of the forearm of six healthy volunteers every 2 h over a 12-h period. The colorimetric values were shown to be site related but hourly variations occurred with similar profiles for all the sites. On Day 2, four topical corticosteroid creams, representative of their potency groups, as well as a base were applied in a randomized double-blind manner on five of the predetermined sites. Visual gradings and colorimetric measurements were carried out every 2 h over the following 12-h diurnal period and were continued on Day 3. The colorimetric parameters L* (luminance) and a* (colour hue ranging from green (-) to red (+)) gave a rank order correlated to corticosteroid potency that showed superior discrimination compared to simple visual grading. In this study, L* was a more discriminative parameter than a*. The Minolta Chroma Meter CR-200 appears to be a simple and accurate device for objectively measuring the blanching effects of topical corticosteroids. Citing Literature Volume124, Issue3March 1991Pages 264-270 RelatedInformation
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