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BIBTEX RIS

Effect of oral activated charcoal on quinine elimination.

1989; Wiley; Volume: 27; Issue: 1 Linguagem: Inglês

10.1111/j.1365-2125.1989.tb05340.x

ISSN

1365-2125

Autores

David Lockey, D. Nicholas Bateman,

Tópico(s)

Drug-Induced Hepatotoxicity and Protection

Resumo

The effect of repeated dose oral activated charcoal on quinine elimination has been studied following a therapeutic (600 mg) dose of quinine bisulphate to seven normal volunteers. Activated charcoal lowered quinine half‐life from 8.23 +/‐ 0.57 s.d. h to 4.55 +/‐ 0.15 s.d. h (P less than 0.001) and increased its oral clearance by 56%. Activated charcoal may have a role in the management of quinine poisoning.

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