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Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.

1988; National Academy of Sciences; Volume: 85; Issue: 21 Linguagem: Inglês

10.1073/pnas.85.21.8161

1091-6490

Makio Iwashima, Adèle C. Green, Mark M. Davis, Yueh-hsiu Chien,

Chemical Synthesis and Analysis

A variable region (V delta 5) of the T-cell receptor (TcR) delta chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3' of the constant region (C delta) element. The V delta 5 coding sequence is in a transcriptional orientation opposite the J delta (joining region) and C delta coding elements and rearranges by inversion. The C delta is divided into four exons, three of which encode amino acids of TcR delta polypeptide, and the fourth comprises the entire 3' untranslated region. In this respect, C delta resembles C alpha rather than C beta or C gamma.